Valerenic acid ( —— )

产品货号. M32098 CAS No. 3569-10-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Valerenic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Valerenic acid is a natural product.
产品描述

Valerenic acid is a natural product.
体外实验

Valerenic acid (1-100 μM) enhances the whole cell currents on GABAA receptors expressed in HEK 293 cells.Valerenic acid exhibits significant affinity for the 5-HT5a receptor, with an IC50 of 17.2 μM (Ki=10.7 μM).[3H]Valerenic acid binds to brain membranes reveals both a high affinity binding site (KD=25 nM) and a low affinity site (KD=16 μM).[3H]Valerenic acid is displaced by Valerenol with high potency (IC50=3 nM).
体内实验

Valerenic acid (1-6 mg/kg i.p. or 10 mg/kg p.o.) decreases the aversion of wild type mice to the lit area.Valerenic acid (10 mg/kg; p.o.) increases the proportion of time 129X1/SvJ mice spent onto the open arms.
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